PLK-3 / Unconjugated /

Product Details
Supplier OriGene
Catalog #: AP14971PU-N (View supplier product page)
Size 400 μl
Price $330.00
Antigen PLK-3
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Mouse
Applications WB
Description Rabbit Polyclonal Anti-PLK3 Antibody, Purified
About PLK-3 and Purified
PLK-3 The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015]
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Purified Excitation and Emission Spectra