NCF4 / Unconjugated / OTI12H10

Product Details
Supplier OriGene
Catalog #: TA809153 (View supplier product page)
Size 100 μl
Price $350.00
Antigen NCF4
Clone OTI12H10
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Target Species Human
Applications IHC
Description NCF4 mouse monoclonal antibody,clone OTI12H10
About NCF4 and Purified
NCF4 The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra