Smad4 / ATTO 700 /

Product Details
Supplier Biorbyt
Catalog #: orb413917-100ug (View supplier product page)
Size 100 μg
Price $575.00
Antigen Smad4
Clone
Host Rabbit
Isotype IgG
Conjugate ATTO 700
Target Species Human
Applications WB
Description Rabbit polyclonal antibody against SMAD4 conjugated to ATTO 700
About Smad4 and ATTO 700
Smad4 This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]
ATTO 700 ATTO 700 from ATTO-Tec Gmbh has an excitation peak at 700 nm and an emission peak at 719 nm.
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ATTO 700 Excitation and Emission Spectra