Skp2 / Biotin /

Product Details
Supplier Biorbyt
Catalog #: orb351092-100ug (View supplier product page)
Size 100 μg
Price $481.10
Antigen Skp2
Clone
Host Rabbit
Isotype IgG
Conjugate Biotin
Target Species Human
Applications ELISA, WB, IHC-P
Description Rabbit polyclonal antibody against SKP2 conjugated to Biotin
About Skp2 and Biotin
Skp2 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
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Biotin Excitation and Emission Spectra