FluoroFinder

	Supplier	Biorbyt
	Catalog #:	orb147728-100ug (View supplier product page)
	Size	100 μg
	Price	$577.00
	Antigen	Rhodopsin
	Clone	4D2
	Host	Mouse
	Isotype	IgG1
	Conjugate	ATTO 390
	Target Species	Human, Porcine, Rat
	Applications	ELISA, WB, IHC-P, IF, ICC, IP
	Description	Mouse monoclonal to Rhodopsin (ATTO 390). Rhodopsin consists of the protein moiety opsin and a reversibly covalently bound cofactor, retinal. Opsin, a bundle of seven membrane embedded alpha-helices, binds retinal, a photo reactive chromophore, in a central pocket. In addition to being the pigment of the retina that is responsible for both the formation of the photoreceptor cells, its function is to specifically convey information stored in the specific geometry of the chormophore to the surface of the molecule upon light absorption. In the active state, rhodopsin activates transduction, a GTP binding protein. Once activated, transduction promotes the hydrolysis of cGMP by phosphodiesterase. Rhodopsins activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin. Mutations in the rhodopsin gene lead to retinitis pigmentosa, which can be inherited as an autosomal dominant, an autosomal recessive or an X-linked recessive disorder..

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Rhodopsin / ATTO 390 / 4D2