Piccolo / Alk Phosphatase / 6H9-B6

Product Details
Supplier Biorbyt
Catalog #: orb147923-100ug (View supplier product page)
Size 100 μg
Price $556.00
Antigen Piccolo
Clone 6H9-B6
Host Mouse
Isotype IgG2b κ
Conjugate Alk Phosphatase
Target Species Human, Rat
Applications ELISA, WB
Description Mouse monoclonal to Piccolo (Alkaline Phosphatase). Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains. In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1..
About Piccolo and Alk Phosphatase
Piccolo The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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Alk Phosphatase Excitation and Emission Spectra