Complement Factor I / Unconjugated / OTI9D10

Product Details
Supplier OriGene
Catalog #: CF806005 (View supplier product page)
Size 100 μg
Price $450.00
Antigen Complement Factor I
Clone OTI9D10
Host Mouse
Isotype IgG2a
Conjugate Unconjugated
Target Species Human
Applications WB
Description Carrier-free (BSA/glycerol-free) CFI mouse monoclonal antibody, clone OTI9D10 (formerly 9D10)
About Complement Factor I and Purified
Complement Factor I This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by RefSeq, Dec 2015]
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Purified Excitation and Emission Spectra