CAMLG / Unconjugated / OTI1A3

Product Details
Supplier OriGene
Catalog #: CF504329 (View supplier product page)
Size 100 μg
Price $450.00
Antigen CAMLG
Clone OTI1A3
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Target Species Human
Applications WB, IHC, IF, FC
Description Carrier-free (BSA/glycerol-free) CAMLG mouse monoclonal antibody, clone OTI1A3 (formerly 1A3)
About CAMLG and Purified
CAMLG The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra