CAMLG / Unconjugated / OTI1H3

Product Details
Supplier OriGene
Catalog #: TA504636 (View supplier product page)
Size 100 μl
Price $350.00
Antigen CAMLG
Clone OTI1H3
Host Mouse
Isotype IgG2b
Conjugate Unconjugated
Target Species Human
Applications WB, IF, FC
Description CAMLG mouse monoclonal antibody, clone OTI1H3 (formerly 1H3)
About CAMLG and Purified
CAMLG The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra