MBD2 / Unconjugated /

Product Details
Supplier Biorbyt
Catalog #: orb185493-100ug (View supplier product page)
Size 100 μg
Price $385.90
Antigen MBD2
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Mouse, Rat
Applications IHC-P, IF, ICC, ELISA
Description Rabbit polyclonal antibody to MBD2
About MBD2 and Purified
MBD2 DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
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Purified Excitation and Emission Spectra