LIMK1 / HRP /

Product Details
Supplier Biorbyt
Catalog #: orb479971-100ug (View supplier product page)
Size 100 μg
Price $451.00
Antigen LIMK1
Clone
Host Rabbit
Isotype IgG
Conjugate HRP
Target Species Human, Mouse, Rat
Applications WB, IHC-P, ELISA
Description Rabbit polyclonal antibody against LIMK1 conjugated to HRP
About LIMK1 and HRP
LIMK1 There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

HRP Excitation and Emission Spectra