HECW2 / Unconjugated /
HECW2 / Unconjugated /
Product Details
| Supplier | Biorbyt | |
|---|---|---|
| Catalog #: | orb224112-100ul (View supplier product page) | |
| Size | 100 μl | |
| Price | $258.40 | |
| Antigen | HECW2 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human, Mouse | |
| Applications | WB, IF, ICC | |
| Description | Rabbit polyclonal antibody to HECW2 |
About HECW2 and Purified
| HECW2 | This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017] |
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Images
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Western blot analysis of A549 (Lane 1), NIH3T3 (Lane 2) whole cell lysates using HECW2 antibody, Immunofluorescense analysis of A549 cells lysates using HECW2 antibody |
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra
$258.40
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