FLI1 / Unconjugated /
FLI1 / Unconjugated /
Product Details
| Supplier | Biorbyt | |
|---|---|---|
| Catalog #: | orb137950-100ug (View supplier product page) | |
| Size | 100 μg | |
| Price | $553.00 | |
| Antigen | FLI1 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human, Mouse, Rat | |
| Applications | WB, IHC-P | |
| Description | Rabbit polyclonal to FLI1. Friend leukemia integration 1 transcription factor, also known as Transcription factor ERGB or Proto-oncogene Fli-1 is a protein that in humans is encoded by the human FLI1 gene. The fli1 protooncogene encodes a member of the ETS family of winged helix-turn-helix transcription factors. This gene is mapped to 11q24.3. Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias. The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway, blocking erythroid differentiation, activating the Ras pathway, and resulting in massive Epo-independent proliferation of erythroblasts. These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event(s) associated with terminal differentiation to proliferation. |
About FLI1 and Purified
| FLI1 | This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
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Images
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Immunohistochemical analysis of formalin-fixed paraffin embedded Rat Spleen Tissue using FLI1 antibody, Western blot analysis of Lane 1: JURKAT Cell Lysate, Lane 2: RAJI Cell Lysate using FLI1 antibody, Immunohistochemical analysis of formalin-fixed paraffin embedded Human Tonsil Tissue using FLI1 antibody |
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra
$553.00
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