ErbB3 / Unconjugated /
ErbB3 / Unconjugated /
Product Details
| Supplier | Biorbyt | |
|---|---|---|
| Catalog #: | orb19129-20ug(TrialSize) (View supplier product page) | |
| Size | 20 μg | |
| Price | $128.00 | |
| Antigen | ErbB3 | |
| Clone | ||
| Host | Goat | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | IHC-P, IF, ICC, FC, ELISA | |
| Description | Goat polyclonal antibody to ERBB3 |
About ErbB3 and Purified
| ErbB3 | This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
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Images
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orb19129 (0.1ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence., orb19129 (5µg/ml) staining of paraffin embedded Human Lung. Steamed antigen retrieval with citrate buffer pH 6, AP-staining., Immunofluorescence analysis of HeLa cells using ERBB3 antibody, Flow cytometric analysis of MCF7 cells using ERBB3 antibody |
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra
$128.00
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