DUSP3 / Unconjugated /
DUSP3 / Unconjugated /
Product Details
| Supplier | Biorbyt | |
|---|---|---|
| Catalog #: | orb39178-400ul (View supplier product page) | |
| Size | 400 μl | |
| Price | $383.00 | |
| Antigen | DUSP3 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | ELISA, WB, IHC-P | |
| Description | Purified rabbit polyclonal antibody. |
About DUSP3 and Purified
| DUSP3 | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008] |
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Images
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Immunohistochemical staining of paraffin embedded human cancer tissue using DUSP3 antibody (primary antibody dilution at: 1:50-100), Western blot analysis of in SK-BR-3 cell line lysates.using DUSP3 antibody (antibody dilution at 1:1000), Western blot analysis of 293 cell lysateusing DUSP3 antibody (primary antibody dilution at: 1:1000) |
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra
$383.00
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