5-Lipoxygenase / DyLight 650 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB110-58749C (View supplier product page)
Size 0.1 ml
Price $449.00
Antigen 5-Lipoxygenase
Clone
Host Rabbit
Isotype IgG
Conjugate DyLight 650
Target Species Bovine, Human, Mouse, Rabbit, Rat
Applications WB
Description Rabbit 5-Lipoxygenase antibody [DyLight 650] detects Human, Mouse, Rat, Bovine, Rabbit
About 5-Lipoxygenase and DyLight 650
5-Lipoxygenase This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
DyLight 650 DyLight™ 650 is a red-emitting fluorophore that excited by the 640 nm laser and collected using a 670/30 nm bandpass filter. DyLight™ 650 has an excitation peak at 652 nm and an emission peak at 672 nm, and is spectrally similar to Alexa Fluor™ 647 and Cy5. DyLight™ 650 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 650 Excitation and Emission Spectra