Cortisol / Unconjugated / CORT-1

Citations: (1)
Product Details
Supplier Biorbyt
Catalog #: orb79379-1mg (View supplier product page)
Size 1 mg
Price $493.00
Antigen Cortisol
Clone CORT-1
Host Mouse
Isotype IgG1 for CORT-1, IgG3 for CORT-2
Conjugate Unconjugated
Target Species Human
Applications
Description Cortisol is a steroid hormone that regulates a wide range of processes throughout the body, including metabolism and the immune response. It also has a very important role in helping the body respond to stress. Cortisol may be oxidised at 11-hydroxt position to result in the production of cortisone, dihydrocortisone, or tetrahydrocortisone. Cortisol and other glucocorticoids bind to the human glucocorticoid receptor (hGR) that is predominantly present in the cytoplasm. On binding, the recptor-ligand complex translocate to nucleus where the transcription of target genes is induced.Deficiency in the levels of 11-HSD are responsible for juvenile hypertension, (a feature of Apparent Mineralocorticoid Excess syndrome), edema, heart failure and hypokalemia (licorice intoxication).
Citations
PMID 26838582
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Purified Excitation and Emission Spectra