CD40 / Cy7 /

Product Details
Supplier Biorbyt
Catalog #: orb123542-100ug (View supplier product page)
Size 100 μg
Price $451.00
Antigen CD40
Clone
Host Rabbit
Isotype IgG
Conjugate Cy7
Target Species Human, Mouse, Rat
Applications
Description Rabbit polyclonal to CD40 (Cy7).
About CD40 and Cy7
CD40 This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
Cy7 Cy7 is an important historical fluorophore from GE Healthcare. It has an excitation peak at 756 nm and an emission peak at 779 nm. Spectrally its similar to Alexa Fluor™ 750.
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Cy7 Excitation and Emission Spectra