BRCA1 / Unconjugated /
BRCA1 / Unconjugated /
Product Details
| Supplier | Biorbyt | |
|---|---|---|
| Catalog #: | orb14621-100ul (View supplier product page) | |
| Size | 100 μl | |
| Price | $325.00 | |
| Antigen | BRCA1 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | WB, IHC-P | |
| Description | Rabbit polyclonal antibody to BRCA1 |
About BRCA1 and Purified
| BRCA1 | This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020] |
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Images
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Immunohistochemical analysis of formalin-fixed and paraffin-embedded human breast carcinoma tissue using BRCA1(Ab-1423) antibody, Western blot analysis of BRCA1(Ab-1423) antibody in Hela and HT29 cells lysate |
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra
$325.00
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