ANK1 / ATTO 680 / S388A-60

Product Details
Supplier Biorbyt
Catalog #: orb376720-100ug (View supplier product page)
Size 100 μg
Price $575.00
Antigen ANK1
Clone S388A-60
Host Mouse
Isotype IgG1
Conjugate ATTO 680
Target Species Human, Rat
Applications WB, IF, ICC
Description Mouse monoclonal antibody against ANK1 conjugated to ATTO 680.
About ANK1 and ATTO 680
ANK1 Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
ATTO 680 ATTO 680 from ATTO-Tec Gmbh has an excitation peak at 680 nm and an emission peak at 700 nm.
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ATTO 680 Excitation and Emission Spectra