MSR1 / Unconjugated / 1D4H8
MSR1 / Unconjugated / 1D4H8
Product Details
| Supplier | Biorbyt | |
|---|---|---|
| Catalog #: | orb69057-100ul (View supplier product page) | |
| Size | 100 μl | |
| Price | $374.00 | |
| Antigen | MSR1 | |
| Clone | 1D4H8 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | ELISA, WB, IHC-P, IF, ICC, FC | |
| Description | Mouse monoclonal antibody to SRA |
About MSR1 and Purified
| MSR1 | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] |
|---|
Images
|
Immunohistochemical analysis of paraffin-embedded human skin carcinoma (left) and breast carcinoma (right) using SRA antibody , Western blot analysis of truncated SRA recombinant protein (lane1), human ovary cancer tissue lysate (lane2) and A431 cell lysate (lane3) using SRA antibody. |
Citations
| Additional Sources |
|
|---|
Reviews & Ratings
Purified Excitation and Emission Spectra
$374.00
Supplier Page
Supplier Page
