SHANK2 / ATTO 594 / S23b-49

Product Details
Supplier Biorbyt
Catalog #: orb148579-100ug (View supplier product page)
Size 100 μg
Price $575.00
Antigen SHANK2
Clone S23b-49
Host Mouse
Isotype IgG1
Conjugate ATTO 594
Target Species Human, Rat
Applications WB, IHC-P, IP
Description Mouse monoclonal to SHANK (ATTO 594). Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins...
About SHANK2 and ATTO 594
SHANK2 This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
ATTO 594 ATTO 594 from ATTO-TEC has an excitation peak at 601 nm and an emission peak at 627 nm. ATTO 594 is a novel fluorescent label belonging to the class of rhodamine dyes. Characteristic features of the label are strong absorption, high fluorescence quantum yield, high thermal and photo-stability, and excellent water solubility. Thus ATTO 594 is highly suitable for single-molecule detection applications and high-resolution microscopy such as PALM, dSTORM, STED etc. Additionally the dye highly qualifies to be applied in flow cytometry (FACS), fluorescence in-situ hybridization (FISH) and many more. ATTO 594 is very hydrophilic and shows a very good water solubility. After coupling to a substrate the label carries a net electrical charge of -1.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

ATTO 594 Excitation and Emission Spectra