CD40 StarBright Violet 440 (LOB7/6, Mouse) - Reactivity: Human
Product Details
| Description | Mouse anti Human CD40:StarBright Violet 440 | |
|---|---|---|
| Conjugate | StarBright Violet 440 | |
| Clone | LOB7/6 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Bio-Rad | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD40
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
About StarBright Violet 440
StarBright Violet 440 (SBV440) is a fluorescent polymer nanoparticle that has an excitation peak at 383 nm and an emission peak at 436 nm, spectrally comparable to SuperBright 436, Pacific Blue and eFluor™ 450. The StarBright family fluorophores from Bio-Rad offers an alternative to the Horizon Brilliant™ polymer series from BD Biosciences including Brilliant™ UV and Brilliant™ Violet.
StarBright Violet 440 (SBV440) is a fluorescent polymer nanoparticle that has an excitation peak at 383 nm and an emission peak at 436 nm, spectrally comparable to SuperBright 436, Pacific Blue and eFluor™ 450. The StarBright family fluorophores from Bio-Rad offers an alternative to the Horizon Brilliant™ polymer series from BD Biosciences including Brilliant™ UV and Brilliant™ Violet.
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